The macrocycle shown below was recently published in Tetrahedron Letters (Volume 51, Issue 10, 10 March 2010, Pages 1361-1363 ) and this time they have a single crystal X-ray structure to back it up. Despite what you might think at first, the ring is closed in very good yield (44-93%) since it exploits the preferred amide-confromation of the secondary aryl benzoic acid amide. This might make an interesting template for drug design.
Kim et al. (Bioorg. Med. Chem Lett. ) assign the structure below to a novel neolignan piperkadsin C. Hmmm??? This can’t be right.
I am not an english major, but shouldn’t it be ‘Named Reactions’ (with a ‘d’) instead of ‘Name Reactions‘. To me a ‘name reaction’ is what you do in response to hearing a name. Like if someone yelled ‘Hey Shlomo’, Shlomo might turn around to see who called out his name
Chapter 1, Pain induced by blunt force trauma (hammers, anvils, car doors, etc…)
Chapter 2, Oral pain (tooth aches, tongue bites…)
Chapter 3, Pain of the foot (stubbed toes, excessive walking…)
Chapter 4, Miscellaneous (heartache…)
I came across an interesting site that provides useful information for anyone interested in computer aided drug design. BindingMoad.org is a database derived from the PDB, but includes only high resolution protein structures with bound ligands. Other information such as binding data is also included.
I was shocked to see how long it has been since I last posted something. It has been much easier to get caught up in other things and let this slip. I am hoping that with this post I can make a new start of it and put up something on a regular basis….at least once a week.
One item for today….Luc Montagnier has won the Nobel prize in medicine for discovering HIV. I imagine this will rankle a few feathers since Robert Gallo, who is also credited the discovery, was not included. For anyone who can remember this is not the first time that there was doubt about Gallo’s role in discovering thie virus. It will be interesting to see how this plays out in the next few weeks.
Personally I am against the idea of assigning credit for any scientific discovery to one or two individuals since it ignores the many other individuals who directly or indirectly contributed.
Role of beer as a possible protective factor in preventing Alzheimer’s disease
M.J. González-Muñoz et al.
Food and Chemical Toxicology, Volume 46, Issue 1, January 2008, Pages 49-56
Phil Baran (from the pre-prof days) and Scott Baio (‘Chachi’ from ‘Happy Days’). The only way I can tell these two apart is that Phil is pictured with KC. I bet if Phil were in high school around the same time I was (circa 1978-1982) he would have been tagged with the nickname ‘Chachi’ like my friend Larry who also bore a striking resemblance to this teen TV star.
Some Interesting Sites:
CrystalEye ”The aim of the CrystalEye project is to aggregate crystallography from web resources, and to provide methods to easily browse, search, and to keep up to date with the latest published information.”
NIH Training Principles of Clinical Pharmacology ”…a series of lectures that cover much of the scientific basis of the bridging discipline of clinical pharmacology.”
UC DAVIS M.I.N.D. Institute Distinguished Lecture Series Webcasts of the distinguished lecture series concerning primarily Autism research.
