http://walkerma.wordpress.com/2007/06/01/new-coupling-reaction/ A medicinal chemist searching for that needle in a haystack Wed, 20 Aug 2008 11:45:45 +0000 http://wordpress.org/?v=MU http://walkerma.wordpress.com/2007/06/01/new-coupling-reaction/#comment-1880 hetchem Mon, 04 Jun 2007 15:10:55 +0000 http://walkerma.wordpress.com/2007/06/01/new-coupling-reaction/#comment-1880 Actually, this reaction seems very interesting at first sight, but as you say Fagnou used a large excess of phenyl, so what about more complex phenyl, regioselectivity, cost, and purification??? That reminds me the iridium catalyzed borylation of aromatic rings by Miyaura and Hartwig they used 10 equiv of phenyl and in some case the reaction were not regioselective and very expensive. This methodology is very narrow, I am not sure that deserves a Science, but C-H activation is " fashion". Actually, this reaction seems very interesting at first sight, but as you say Fagnou used a large excess of phenyl, so what about more complex phenyl, regioselectivity, cost, and purification???
That reminds me the iridium catalyzed borylation of aromatic rings by Miyaura and Hartwig they used 10 equiv of phenyl and in some case the reaction were not regioselective and very expensive.
This methodology is very narrow, I am not sure that deserves a Science, but C-H activation is ” fashion”.

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