Intersting structure???

Kim et al. (Bioorg. Med. Chem Lett. ) assign the structure below to a novel neolignan piperkadsin C.  Hmmm??? This can’t be right.

 

Name Reactions Misnamed?

I am not an  english major, but shouldn’t it be ‘Named Reactions’  (with a ‘d’) instead of  ‘Name Reactions‘.  To me a ‘name reaction’ is what you do in response to hearing a name. Like if someone yelled ‘Hey Shlomo’, Shlomo might turn around to see who called out his name

11-13-2008 A Must Read

Chapter 1, Pain induced by blunt force trauma (hammers, anvils, car doors, etc…)

Chapter 2, Oral pain (tooth aches, tongue bites…)

Chapter 3, Pain of the foot (stubbed toes, excessive walking…)

Chapter 4, Miscellaneous (heartache…)

long overdue update

I was shocked to see how long it has been since I last posted something. It has been much easier to get caught up in other things and let this slip. I am hoping that with this post I can make a new start of it and put up something on a regular basis….at least once a week.

One item for today….Luc Montagnier has won the Nobel prize in medicine for discovering HIV. I imagine this will rankle a few feathers since Robert Gallo, who is also credited the discovery, was not included. For anyone who can remember this is not the first time that there was doubt about Gallo’s role in discovering thie virus. It will be interesting to see how this plays out in the next few weeks.

Personally I am against the idea of assigning credit for any scientific discovery to one or two individuals since it ignores the many other individuals who directly or indirectly contributed.

For Medicinal Purposes…

Role of beer as a possible protective factor in preventing Alzheimer’s disease

M.J. González-Muñoz et al. 

Food and Chemical Toxicology, Volume 46, Issue 1, January 2008, Pages 49-56

doi:10.1016/j.fct.2007.06.036  

Seprated at birth

Eric….the present look says Anderson Cooper but will be there any relation to Mr. Burns in the future?

                              

Eric                                                 Anderson Cooper

  

Mr. Burns.

Silica not just for chromotagraphy…

The following title caught my eye…It is interesting to note that while silica-packets that accompany moisture sensitive products have a “do not ingest” warning, silica is included as an ingredient in a lot of food-products. Take a look at most powdered mixes and you will see it as an ingredient.

Martin, K. R. The chemistry of silica and its potential health benefits. Journal of Nutrition, Health & Aging (2007), 11(2), 94-98

Separated at birth…?

Haven’t had time to post any article reviews so I thought I would add some more…This time Andy Myers and Wally Clever…

 

Src and Syk kinase attenuation of HIV infection

A recent paper in The Journal of Immunology (2007, p2862) (no DOI?) concerning the role which two kinases (Src and Syk) play in the early steps of HIV infection, is interesting in a number of ways. Firstly, it reveals how these kinases might attenuate the infection early-on and second, it shows how a drug might have a completely unexpected adverse effect.

HIV, in most cases, enters the body by hitching a ride in dendritic cells (DCs) which are located in the mucosal lining of exposed tissues. The virus doesn’t infect these cells, it merely binds to cell surface receptors (eg. the mannose receptor or DC-SIGN) and is internalized into endolysosomal vacuoles. Migration of the DCs to the lymph nodes where the virus is passed on to CD4⁺ T-cells initiates the actual infection.

Tremblay and co-workers found that if inhibitors of the Src or Syk kinases, PP2 and piceatannol, were present during the transfer of the virus from the DCs to the CD4⁺T-cells (in cell culture) that the overall amount of virus that was present, afterwards, was higher than in their absence. The same result occurred if they used siRNA to knockdown the kinases. After additional experiments it was apparent that the kinase-inhibitors were causing the DCs, themselves, to become infected.

One might conclude from these experiments, that under normal circumstances the kinases “protect” the DCs from becoming infecting, allowing them to act as passive transporters of the virus to the lymph-nodes. How this occurs can only be speculated. One idea offered by the authors is that the inhibitors cause the virus to be shuttled to the cytoplasm of the DCs instead of the endolysosomal vacuole, whereupon it infects the cell.

I am probably thinking too hard about this but…a question not addressed in this paper, is what would happen to a person who is at high risk of becoming infected with HIV if they were on a drug regimen that included a Src or Syk inhibitor? Would there chances of becoming infected increase?

 

Fixed links

Links in the carboxylic acid isostere section have been fixed….Now I know how to link to a DOI properly.